Global Journal of Multidisciplinary and Applied Sciences

The Role Of Gut Microbiota In Modulating Immune Responses: Implications For Precision Medicine

Shahbaz Ahmed

Department of Microbiology, Aga Khan University, Karachi, Pakistan

Keywords: Gut Microbiota, Immune Modulation, Precision Medicine, Microbiome Therapeutics

Abstract

 The gut microbiota is a complex ecosystem that plays a pivotal role in shaping the host immune system. Emerging evidence demonstrates that alterations in gut microbial composition influence immune responses, contributing to susceptibility to infections, autoimmune disorders, and inflammatory diseases. Precision medicine approaches increasingly leverage gut microbiota profiling to tailor therapeutic strategies, including probiotics, prebiotics, fecal microbiota transplantation, and personalized dietary interventions. This article evaluates the mechanisms by which gut microbiota modulates immunity, examines translational applications in precision medicine, and highlights challenges in integrating microbiome-based interventions into clinical practice. Understanding these interactions offers potential for individualized therapies that optimize immune function and disease outcomes.